Publications and Presentations
Recent publications (since Dr. Fluckey’s arrival) with investigators affiliated with the MBL include:
Dupont-Versteegden EE, BA Strotman, CM Gurley, D Gaddy, M Knox, JD Fluckey, and Peterson CA. Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei. Am J Physiol Regul Integr Comp Physiol. In Press, 2006.
Dupont-Versteegden EE, JD Fluckey, M Knox, D Gaddy, and CA Peterson. The effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult rats. J. Appl. Physiol. 101:202-12, 2006.
Fluckey JD, M Knox, LM Smith, EE Dupont-Versteegden, D Gaddy, PA Tesch, and CA Peterson. The insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP-kinase pathway. Am. J. Physiol – Endocrinol.& Metab. 290:E1205-11, 2006.
Hays NP, RD Starling, DH Sullivan, JD Fluckey, RH Coker, and WJ Evans. Comparison of insulin sensitivity assessment indices with euglycemic-hyperinsulinemic clamp data following a dietary and exercise intervention in older adults. Metab.: Clin. and Exp. 55: 525-532, 2006.
Hays NP, RD Starling, DH Sullivan, JD Fluckey, RH Coker, RH Williams, JA Carrithers and WJ Evans. Effects of an ad libitum high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women. J. Gerontol.: Biol. Sci. and Med. Sci.: 61A(3):299-304, 2006.
Carroll CC, Fluckey JD, Williams RH, Sullivan DH and Trappe TA. Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion. Am J Physiol Endocrinol Metab 288: E479-E485, 2005.
Manuscripts from the MBL
Nilsson MI, Greene NP, Dobson JP, Wiggs MP, Gasier HG, Macias BR, Shimkus KL and Fluckey JD. Insulin resistance syndrome blunts the mitochondrial anabolic response following resistance exercise. Am J Physiol Endocrinol Metab 2010. PMID: 20606077
Gasier HG, Fluckey JD and Previs SF. The application of 2H2O to measure skeletal muscle protein synthesis. Nutr Metab (Lond) 7: 31, 2010. PMID: 20409307
Gasier HG, Previs SF, Pohlenz C, Fluckey JD, Gatlin DM 3rd, Buentello JA. A novel approach for assessing protein synthesis in channel catfish, Ictalurus punctatus. Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):235-8. Epub 2009 Jun 27. PMID: 19563906
Gasier HG, Riechman SE, Wiggs MP, Previs SF, Fluckey JD. A comparison of 2H2O and phenylalanine flooding dose to investigate muscle protein synthesis with acute exercise in rats. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E252-9. Epub 2009 Apr 14. PMID: 19366878
Abstracts Presented at Regional, National or International Conferences. Authors in bold print represent students in the MBL.
Davis, AR, L Schilling, E Wellberg, B Macias, W Porter, S Riechman, JD Fluckey. Chemotherapeutic properties of myokines relased from ‘e-stim’ skeletal muscle.
Presented at the International Biochemistry of Exercise meeting, Guelph, Ontario, Canada, June 2009.
Dobson, JP, MI Nilsson, NP Greene, MP Wiggs, GS Latham, S Walters, and JD Fluckey. Reduced muscle mass in hindlomb muscles of obese Zucker rats is not due to suppressed protein synthesis.
Presented at the International Biochemistry of Exercise meeting, Guelph, Ontario, Canada, June 2009.
Greene, NP, MI Nilsson, RO Hodlik, JD Fluckey, SF Crouse. Influence of resistance exercise on AMPK AND PGC-1α in the obese Zucker rat.
Presented at the International Biochemistry of Exercise meeting, Guelph, Ontario, Canada, June 2009.
Nilsson, MI, NP Green, JP Dobson, BR Macias, MP Wiggs, HG Gasier, and JD Fluckey. Resistance exercise does not augment cumulative muscle protein synthesis in the obese Zucker rat. .
Presented at the International Biochemistry of Exercise meeting, Guelph, Ontario, Canada, June 2009.
Riechman SE, A Davis, TV Lee, V Chen, CW Lee and JD Fluckey. Skeletal muscle endocrine factors.
Presented at the International Biochemistry of Exercise meeting, Guelph, Ontario, Canada, June 2009.
Shimkus KL, MP Wiggs, MI Nilsson, JD Fluckey. Effects of acute resistance exercise on signaling markers of protein synthesis in a simulated microgravity environment.
Presented at the International Biochemistry of Exercise meeting, Guelph, Ontario, Canada, June 2009.
Wiggs, MP, MI Nilsson, GS Latham, S Walters, K Flores, K Allender, JD Fluckey. Expression of Atrogin-1 is not increased in soleus or plantaris after 5 days of hindlimb unloading in rats.
Presented at the International Biochemistry of Exercise meeting, Guelph, Ontario, Canada, June 2009.
Gasier HG, SF Previs, TV Lee, V Chen , MP Wiggs, SE Riechman, JD Fluckey. A comparison of 2H2O and phenylalanine flooding dose methodologies to investigate muscle protein synthesis rates in rats.
Presented at the Integrative Biology of Exercise Meeting, Hilton Head, SC, Sept. 2008.
Wiggs MP, HG Gasier, SF Previs, JD Fluckey. Assessment of cumulative FSR over a 24 h period with hindlimb unloading and intermittent reloading in rats.
Presented at the Integrative Biology of Exercise Meeting, Hilton Head, SC, Sept. 2008.
Gasier HG, MP Wiggs, JM Swift, D Oliphant, SA Riechman and JD Fluckey. Plateau effects of resistance exercise result from over-expression of eIF4E-BP1.
Presented at Experimental Biology 2007, Washington DC, May 2007; Manuscript in preparation.
Wiggs MP, KP Jones, W Rayburn, T Davis, GL Dohm, and JD Fluckey. Insulin signaling in sedentary human skeletal muscle via PI3K is necessary for protein synthesis.
Presented at Experimental Biology 2007, Washington DC, May 2007; Manuscript in preparation.
Fluckey JD, L Norrbrand, M Pozzo, L Smith and PA Tesch. Insulin is not necessary for post exercise elevations of muscle protein synthesis after 5 weeks of resistance exercise training.
Presented at FASEB Conference, San Francisco, CA, 2006.
Swift JM, F vonWalden, T Elman, JD Fluckey and SA Bloomfield. Assessing the Efficacy of Multiple Dosing Regimens of a ß-Agonist Agent for Bone and Muscle Loss During 28d Hindlimb Unloading.
Texas ASCM, September, 2005.
Invited Lectures/Symposia
Mini-Symposium on Studies of Microgravity: The Need for Biomedical Research. The symposium was sponsored by the Department of Health and Kinesiology and the Sydney and JL Huffines Institute for Sports Medicine and Human Performance – 2006. The speakers included Dr. Per Tesch, Karolinska Institute, Dr. Bloomfield, Bone Biology Lab, TAMU, Dr. Fluckey, Muscle Biology Lab, TAMU and Richard Linnehan, NASA.
Invited Speaker, California State University – Department of Kinesiology – Chico – April 6, 2006
Invited Speaker, University of Texas – Department of Kinesiology – November 17, 2006
Invited Speaker, University of Kentucky – College of Medicine – November 28, 2007
Invited Speaker, Texas A&M University – College of Education and Human Development Advisory Council – October 10, 2008
Invited Speaker, Texas Chapter – American College of Sports Medicine: High intensity exercise training; new insight related to the control of muscle mass and disease prevention. Tyler, TX, February 27, 2009.